Effects of hemin on cells

Effects of Hemin on Cells

Upon destruction of erythrocytes, a process also called hemolysis, haemoglobin and, subsequently, free protoporphyrin IX (also called free heme or hemin) is released. Free heme is well known for its cytotoxic and pro-inflammatory properties. For instance, upon incubation of neutrophils with heme a stronger production of reactive oxygen species (ROS) by the cells was observed. In experiments with erythrocytes we could show that free heme induces further haemolytic events, leading to a vicious circle between heme release and further hemolysis.

Upon pre-incubation of hemin with chlorite (ClO2-) we were able to efficiently inhibit the haemolytic effect of free heme

Team Members

Dr. Jörg Flemmig, Denise Schlorke, Prof. Dr. Jürgen Arnhold

Collaborations

Dr. Paiboon Maraprygsavan
Police General Hospital, Bangkok, Thailand

Dr. Friedrich-Wilhelm Kühne
OXO Chemie (Thailand) Co. Ltd, Bangkok, Thailand

letzte Änderung: 10.07.2017