Peroxidase activity of Aβ heme complexes

Peroxidase Activity of Aβ Heme Complexes

A key feature of Alzheimer's disease is the extracellular deposition of amyloid β (Aβ) plaques into so-called senile plaques. Yet the pathological importance of the peptide is still under discussion. As literature data about a peroxidase activity of Aβ in complex with free heme exist we currently investigate the enzymatic activity of Aβ heme complexes in dependence e.g. on the Aβ heme ratio or the pH value. One key aspect is the dependence of the peroxidase activity on the Aβ peptide sequence as in the presence of the murine peptide only a low enzymatic activity was observed. Furthermore we also investigate the formation of dityrosine bridges due to the peroxidase activity as well as the influence of dityrosine formation on the fibrillation behaviour of Aβ. We hope that these studies will contribute to a better understanding of the pathological role of Aβ in Alzheimer's disease. The results of our in vitro-studies are compared to in vivo-studies with mouse models of the disease.

Team Members

Dr. Jörg Flemmig, Prof. Dr. Jürgen Arnhold

Collaborations

Prof. Dr. Alia Alia (Matysik)
University of Leipzig, Leipzig, Germany
 

Prof. Dr. Herman Spaink
Leiden University, Leiden, The Netherlands

letzte Änderung: 24.05.2017