Curriculum Vitae

CV of Prof. Dr. Peter Hildebrand

Name/Position
Name

Prof. Dr. rer. nat. habil. Peter Hildebrand

born in Burglengenefld, Germany, on 14/11/1968

married, three children

Position

ProteinFormatics Laboratory

Institute of Medical Physics and Biohysics

University of Leipzig 

Education and Training
1989 - 1992Studies of Biology, University of Regensburg
1991Pre-degree in Biology
1993 - 1994Studies of Biology/Ecology, University of Sevilla, Spain
19942-month internship at the Institute of Natural and Nutritional Science of Sevilla, Spain
1995 - 1997Studies of Biology, University of Regensburg, final examination in 1997
1997 - 1998Diploma Thesis at the Ecological Faculty of Humboldt University Berlin
1998Awarded Diploma in Biology by Humboldt University Berlin
1999 - 2002PhD Student at the graduate college "Model Studies of Structure, Behaviour and Recognition of Biomolecules in Atomic Resolution"
2003

Awarded the title "Doktor rerum naturalium" (Dr. rer. nat.) by Humboldt University Berlin.

Title of the Dissertation Thesis: Tertiary Structure Modelling of Helical Membrane Proteins"

2008 - 2011Habilitation Dissertation Thesis: Structure-Function Relationships of Helical Membrane Proteins: Implications for 3D Modelling"
2011Habilitation in Biophysics at Charité Universitätsmedizin Berlin
2010 - 2012Advanced education in the ESF qualifying Programme for teaching
Academic Positions
2003-2005Post-doctoral fellow at the Institute of Biochemistry, Humboldt University Berlin in the Protein Structure Theory Laboratory of Prof. Dr. Cornelius Frömmel
2005-2007Post-doctoral fellow at the Institute of Molecular Biology and Bioinformatics of the Free University Berlin, in the Structural Bioinformatics Laboratory of PD Dr. Robert Preißner
2008-2017Head of the ProteinFormatics laboratory at the Institute of Medical Physics and Biophysics, Charité Universitätsnedizin Berlin
2009-2010Guest scientist at the Los Alamos National Laboratory, New Mexico, U.S.A.
2017 - datoGuest Professor at the Institute of Medical Physics and Biophysics, Charité Universitätsmedizin Berlin. Co-PI with BIH Einstein Visiting Fellow Prof. Dr. Brian Kobilka ,Stanford University, of the Project "in silico GPCR"
2017 - datoProfessor at the Institute for Medical Physics and Biophysics, Leipzig University

   

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Selected Publications

  1. Szczepek, M., Beyrière, F., Hofmann, K. P., Elgeti, M., Kazmin, R., Rose, A., Bartl, F. J., Stetten von, D., Heck, M., Sommer, M. E., Hildebrand, P. W. and Scheerer, P (2014). Crystal structure of a common GPCR binding interface for G protein and arrestin, Nat. Commun., 10, 4801.
  2. Rose A.S., Elgeti M., Zacchariae U., Grubmüller H., Hofmann K.P., Scheerer P. and Hildebrand P.W. (2014) Position of transmembrane helix 6 determines receptor g protein coupling specificity.J Am Chem Soc, 32, 11244-7.
  3. Budkevich T.V., Giesebrecht J., Ramrath D., Mielke T., Ismer J., Hildebrand P.W., Tung C.S., Nierhaus K.H., Sanbonmatsu K.Y. and Spahn C.M.T. (2014) Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement,Cell, 1, 121-31.
  4. Elgeti M., Rose A.S., Bartl F.J., Hildebrand P.W., Hofmann K.P. and Heck M. (2013) Precision vs. flexibility in GPCR signalling. J Am Chem Soc, 33, 12305-12.
  5. Munter L.M., Sieg H., Bethge T., Liebsch F., Bierkandt F.S., Schleeger M., Bittner H.J., Heberle J., Jakubowski N., Hildebrand P.W., Multhaup G. (2013) Model peptides uncover the role of the BACE1 transmembrane sequence in metal-ion mediated oligomerization, J Am Chem Soc, 51, 19354-61.
  6. Richter, L., Munter, L.M., Ness, J., Hildebrand, P.W., Dasari, M., Unterreitmeier, S., Bulic, B., Beyermann, M., Gust, R., Reif, B. et al. (2010) Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proc Natl Acad Sci U S A, 107, 14597-14602.
  7. Hildebrand, P.W., Scheerer, P., Park, J.H., Choe, H.W., Piechnick, R., Ernst, O.P., Hofmann, K.P. and Heck, M. (2009) A ligand channel through the G protein coupled receptor opsin. PLoS ONE, 4, e4382.
  8. Scheerer, P., Heck, M., Goede, A., Park, J.H., Choe, H.W., Ernst, O.P., Hofmann, K.P. and Hildebrand, P.W. (2009) Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface. Proc Natl Acad Sci U S A, 106, 10660-10665.
  9. Scheerer, P., Park, J.H., Hildebrand, P.W., Kim, Y.J., Krauss, N., Choe, H.W., Hofmann, K.P. and Ernst, O.P. (2008) Crystal structure of opsin in its G-protein-interacting conformation. Nature, 455, 497-502.
  10. Hildebrand, P.W., Rother, K., Goede, A., Preissner, R. and Frommel, C. (2005) Molecular packing and packing defects in helical membrane proteins. Biophys J, 88, 1970-1977.

 

 

 

 

 

 

 

 

 

 

 

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letzte Änderung: 04.07.2017