Curriculum Vitae
Content
CV of Prof. Dr. Peter Hildebrand
| Name/Position | |
| Name | Prof. Dr. rer. nat. habil. Peter Hildebrand born in Burglengenefld, Germany, on 14/11/1968 married, three children |
| Position | ProteinFormatics Laboratory Institute of Medical Physics and Biohysics University of Leipzig |
| Education and Training | |
| 1989 - 1992 | Studies of Biology, University of Regensburg |
| 1991 | Pre-degree in Biology |
| 1993 - 1994 | Studies of Biology/Ecology, University of Sevilla, Spain |
| 1994 | 2-month internship at the Institute of Natural and Nutritional Science of Sevilla, Spain |
| 1995 - 1997 | Studies of Biology, University of Regensburg, final examination in 1997 |
| 1997 - 1998 | Diploma Thesis at the Ecological Faculty of Humboldt University Berlin |
| 1998 | Awarded Diploma in Biology by Humboldt University Berlin |
| 1999 - 2002 | PhD Student at the graduate college "Model Studies of Structure, Behaviour and Recognition of Biomolecules in Atomic Resolution" |
| 2003 | Awarded the title "Doktor rerum naturalium" (Dr. rer. nat.) by Humboldt University Berlin. Title of the Dissertation Thesis: Tertiary Structure Modelling of Helical Membrane Proteins" |
| 2008 - 2011 | Habilitation Dissertation Thesis: Structure-Function Relationships of Helical Membrane Proteins: Implications for 3D Modelling" |
| 2011 | Habilitation in Biophysics at Charité Universitätsmedizin Berlin |
| 2010 - 2012 | Advanced education in the ESF qualifying Programme for teaching |
| Academic Positions | |
| 2003-2005 | Post-doctoral fellow at the Institute of Biochemistry, Humboldt University Berlin in the Protein Structure Theory Laboratory of Prof. Dr. Cornelius Frömmel |
| 2005-2007 | Post-doctoral fellow at the Institute of Molecular Biology and Bioinformatics of the Free University Berlin, in the Structural Bioinformatics Laboratory of PD Dr. Robert Preißner |
| 2008-2017 | Head of the ProteinFormatics laboratory at the Institute of Medical Physics and Biophysics, Charité Universitätsnedizin Berlin |
| 2009-2010 | Guest scientist at the Los Alamos National Laboratory, New Mexico, U.S.A. |
| 2017 - dato | Guest Professor at the Institute of Medical Physics and Biophysics, Charité Universitätsmedizin Berlin. Co-PI with BIH Einstein Visiting Fellow Prof. Dr. Brian Kobilka ,Stanford University, of the Project "in silico GPCR" |
| 2017 - dato | Professor at the Institute for Medical Physics and Biophysics, Leipzig University |
Selected Publications
- Szczepek, M., Beyrière, F., Hofmann, K. P., Elgeti, M., Kazmin, R., Rose, A., Bartl, F. J., Stetten von, D., Heck, M., Sommer, M. E., Hildebrand, P. W. and Scheerer, P (2014). Crystal structure of a common GPCR binding interface for G protein and arrestin, Nat. Commun., 10, 4801.
- Rose A.S., Elgeti M., Zacchariae U., Grubmüller H., Hofmann K.P., Scheerer P. and Hildebrand P.W. (2014) Position of transmembrane helix 6 determines receptor g protein coupling specificity.J Am Chem Soc, 32, 11244-7.
- Budkevich T.V., Giesebrecht J., Ramrath D., Mielke T., Ismer J., Hildebrand P.W., Tung C.S., Nierhaus K.H., Sanbonmatsu K.Y. and Spahn C.M.T. (2014) Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement,Cell, 1, 121-31.
- Elgeti M., Rose A.S., Bartl F.J., Hildebrand P.W., Hofmann K.P. and Heck M. (2013) Precision vs. flexibility in GPCR signalling. J Am Chem Soc, 33, 12305-12.
- Munter L.M., Sieg H., Bethge T., Liebsch F., Bierkandt F.S., Schleeger M., Bittner H.J., Heberle J., Jakubowski N., Hildebrand P.W., Multhaup G. (2013) Model peptides uncover the role of the BACE1 transmembrane sequence in metal-ion mediated oligomerization, J Am Chem Soc, 51, 19354-61.
- Richter, L., Munter, L.M., Ness, J., Hildebrand, P.W., Dasari, M., Unterreitmeier, S., Bulic, B., Beyermann, M., Gust, R., Reif, B. et al. (2010) Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proc Natl Acad Sci U S A, 107, 14597-14602.
- Hildebrand, P.W., Scheerer, P., Park, J.H., Choe, H.W., Piechnick, R., Ernst, O.P., Hofmann, K.P. and Heck, M. (2009) A ligand channel through the G protein coupled receptor opsin. PLoS ONE, 4, e4382.
- Scheerer, P., Heck, M., Goede, A., Park, J.H., Choe, H.W., Ernst, O.P., Hofmann, K.P. and Hildebrand, P.W. (2009) Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface. Proc Natl Acad Sci U S A, 106, 10660-10665.
- Scheerer, P., Park, J.H., Hildebrand, P.W., Kim, Y.J., Krauss, N., Choe, H.W., Hofmann, K.P. and Ernst, O.P. (2008) Crystal structure of opsin in its G-protein-interacting conformation. Nature, 455, 497-502.
- Hildebrand, P.W., Rother, K., Goede, A., Preissner, R. and Frommel, C. (2005) Molecular packing and packing defects in helical membrane proteins. Biophys J, 88, 1970-1977.
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