Innovative tools to study the impact and mode of action of micro and nanoplastics on human health: towards a knowledge base for risk assessment.

Launched in April 2021. Duration 4 years

The project PLASTICHEAL is supported by European Commission in the framework of Horizon 2020,  Grant N°: 965196

 

PLASTICHEAL, together with AURORA , IMPTOX , PlasticsFatE , and POLYRISK, is one of the five European main research projects currently working to understand micro- and nanoplastics (MNPLs) in our environment and their exposures and impacts on health. These projects are funded under a call within the European Union’s Horizon 2020 program. To optimise synergies, these five projects have formed the European Research Cluster to Understand the Health Impacts of Micro- and Nanoplastic (CUSP).

Primary microplastics that produced intentionally as well incidental secondary microplastics  could degraded to nanoscale particles at environmental conditions. These particles are persistent and accumulate in abiotic and biotic environments. Ingestion of food and inhalation of plastics are two main routes of human exposure to micro and nanoplastics (MNPLs). However, there is only very limited information on their potential impact on human health. In this context, the PLASTICHEAL project aims at providing new methodologies and evidence to regulators by combining the use of breakthrough research and reliable test methods to set the knowledge basis for adequate risk assessment of MNPLs. The team of Dr. Estrela-Lopis is involved in four workpages, such as Enviromental Monitoring, Human Biomonitoring, Impact on GIT(gastrointestinal)&RT(respiratory) barriers and Fate& Bioaccumulation in vivo models.

The main issues to be addressed by Leipzig group:

  • methodology development towards the needs of detection, chemical identification, quantification and visualization of MNPLs in air, food, water as well in urine, blood, faeces, exhaled breath condensates of patients undergoing frequent dialysis as well of workers of the plastic industry and in greenhouses;
  • transformation and degradation monitoring of MNPLs in biological and environmental media;
  • visualization and quantification of translocation of MNPLs through barriers  and their  uptake   at subcellular level in single cells by means of high resolution space resolved element and molecule based analysis; 
  • monitoring of plastic induced biochemical changes and their interaction with biomolecules within single living cells;
  • study of fate and bioaccumulation in in vivo models using 3D-CRM (confocal Raman microscopy) and element based dosimetric imaging.

 

Project partners:

N

SHORT NAME

PARTICIPANT ORGANISATION NAME

TYPE*

COUNTRY

1*

UAB

Universitat Autònoma de Barcelona

RES

ES

2

FIOH

Finnish Institute of Occupational Health

RES

FI

3

WUR

Wageningen University & Research

RES

NL

4

DTU

Technical University of Denmark

RES

DK

5

CEA

Commissariat à l’Energie Atomique et aux Energies Alternatives

RES

FR

6

IMIB

BioMedical Research Institute of Murcia

RES

ES

7

UNIMAN

University of Manchester

RES

UK

8

AIMPLAS

Instituto Tecnológico del Plástico

TC

ES

9

CRCL

Centre de Recherche en Cancérologie de Lyon

RES

FR

10

UFZ

Helmholtz-Center for Environmental Research

RES

GER

11

ULEI

University of Leipzig

RES

GER

Address

Press

Fakultätsverwaltung/Öffentlichkeitsarbeit
Peggy Darius
Liebigstr. 27
04103 Leipzig

Tel. 97-15798

Logo Medizinische Fakultät

Liebigstr. 27
04103 Leipzig

VAT No.  DE141510384