Role of iron in development of peripheral diabetic neuropathy

Trace element analysis of nerve cells in the rat model of peripheral diabetic neuropathy

This project aims to explain the role of iron metabolism dysfunction in the development of peripheral diabetic neuropathy in type 1 diabetes and to recognize novel possible targets for drugs related to peripheral nerve cell protection.  Ion Beam Microscopy, Confocal Raman Microspectroscopy, ATR-FTIR, TEM, Toxicological/Physiological assays in vivo and in vitro will be applied to analyze the dysfunction of iron metabolism and its impact on peripheral diabetic neuropathy pathogenesis.

Fig.1 Distribution of sulfur and iron in dorsal root ganglions (DRG) of healthy and streptozotocin (STZ)-induced diabetic rats. The iron concentration was significantly increased in DRG neurons of STZ rats compared with control ones.