Prof. Dr. Alia A. Matysik

Team
Publications
Personal
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Research Interests

Magnetic Resonance Microimaging (μMRI) of Alzheimer's Disease (AD)

Alzheimer’s disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment of Alzheimer’s disease lies in the inability to definitively diagnose a patient. The development of a non-invasive method to detect early, subtle changes in the brains of patients with Alzheimer’s disease can greatly improve early diagnosis and accurate clinical evaluation of AD.

In my group we are developing non-invasive magnetic resonance imaging (μMRI) methods to visualize amyloid plaque development in vivo in transgenic mouse models of AD at ultra high magnetic fields (7T, 9.4T and 17.6T). In addition, cerebral amyloid angiopathy (CAA) related blood flow defects are being examined using magnetic resonance angiography. For understanding the mechanism of AD progression, we are getting direct access to the in vivo metabolic profile with very high selectivity and resolution using localized version of two dimensional magnetic resonance spectroscopy (L-COSY, J-PRESS), which we recently developed for accessing the chemistry of the live mouse brain. Within the network of collaboration between the Paul Flechsig Institute for brain research, the Institute for Medical Physics and Biophysics at Leipzig University and the University of Leiden (The Netherlands), we are particularly interested in: (1) dissecting the underlying mechanism for gender related differences in AD progression and (2) understanding the role of altered biological clock in Alzheimer’s disease.

Collaborations:

  • Prof. Dr. S. Roßner, Prof. Dr. T. Arendt, Prof. Dr. R. Schliebs, Paul-Flechsig-Institute for Brain Research, Leipzig University.Prof.
  • Prof. Dr. M.A. van Buchem, Leiden University.

Reference number TRR-386-A1-08/2024

A Ph.D. position is currently available in the group of Prof. A. Alia Matysik (Faculty of Medicine, Institute of Medical Physics and Biophysics) in collaboration with Prof. Jörg Matysik at the Faculty of Chemistry and Mineralogy, Institute of Analytical Chemistry, at Leipzig University. The position is funded by the German Research Foundation (DFG) within the Collaborative Research Centre TRR-386 “Hyperpolarization in Molecular Systems.”

Within TRR-386, the Ph.D. student will work on a project aimed at improving the sensitivity, contrast, and spatial resolution of magnetic resonance imaging (MRI) through the application of photo-CIDNP hyperpolarization for medical applications.

Requirements:

  • MSc in (bio)physics, chemistry, or biochemistry.
  • Background in NMR or MRI is appreciated but not required.
  • Interest in hyperpolarization and optical techniques.
  • Ability to work independently and creatively.

About the Position:

  • Fixed term of 3 years, with the possibility of extension for another 9 months.
  • Up to 75% of a full-time position.
  • Planned remuneration: salary group E13 TV-L.

What We Offer:

  • A modern workplace and attractive working conditions (including mobile working).
  • Flexible working hours and work-life balance.
  • Goal-oriented staff development throughout your career, with opportunities for continuing professional development.
  • Pension plan.
  • Commuter pass for the MDV network.
  • Excellent access to interdisciplinary perspectives, e.g., within the Integrated Research Training Group of the SFB.

Interested candidates should send their application and CV to info@hypmol.net by August 30, 2024.

Enquiries about the project can be directed to: Prof. A. Alia Matysik (Institute of Medical Physics and Biophysics; alia.aliamatysik@medizin.uni-leipzig.de) or Prof. Jörg Matysik (Institute of Analytical Chemistry; joerg.matysik@uni-leipzig.de).

Magnetic Resonance Imaging of the Adult Zebrafish

Zebrafish is an excellent model organism for studying various human diseases. Due to opaqueness of the adult phase, in vivo studies are restricted to early embryonic stages. This raises the need for rapid sensitive and non-invasive in vivo imaging methods to follow developmental processes, not only of the embryonic phase but also of juvenile and adult stages. In my group we are developing μMRI methods for imaging live zebrafish. Furthermore, we are developing and applying 1H, 13C and 31P MR spectroscopic and imaging methods for studying changes in metabolic profile associated with various diseases in zebrafish. MR methods have been successfully employed to get access to the disease pathology in zebrafish models for malignant melanoma, cystic leukoencephalopathy, megalencephalic leukoencephalopathy and model for Lowe syndrome. In addition to adult fish, the metabolic profiling in intact zebrafish embryos at various developmental stages is being approached by HR-MAS NMR. In cooperation with Prof. Berry (Miami, Florida), we are deveolpping novel applications of HR-MAS NMR as a toxicological tool to specifically examined metabolic changes of embryos exposed to environmental neurotoxins.

Collaborations:

  • John P. Berry, Florida International University
  • Prof. H.J.M. de Groot, Prof. H. Spaink, Prof. M.K. Richardson, Leiden University
  • Dr. R. Estevz Povedano, University of Barcelona
  • Dr. Katharina Ternka and Dr. Matthias Kettwig, University Medical Center Göttingen

Principal Investigator

Prof. Dr. Alia Matysik (A.Alia)

Photo_Alia2_07052024

Härtelstr. 16-18, 04107 Leipzig
Room 351.1
Phone +49(0)341 97-15707
Email

ORCID-ID 0000-0002-4900-9749

Team

Hashem Eeza, Muhamed Nour, doctoral student

Bashirova, Narmin, doctoral student

Singer, Rico, doctoral student from Leiden University

Personal

CV Prof. Dr. Alia A. Matysik

  • Since 2014: Group leader, Institute for Medical Physics and Biophysics, Leipzig University from Jan 2014-till date.
  • Since 2007: Assistant Professor (tenure), Leiden Institute of Chemistry, Leiden University from June 1, 2007-till date.
  • 1997-2007: Scientific Researcher at Leiden Institute of Chemistry, Leiden University.
  • 1996-1997: Japan Society for Promotion of Science (JSPS) fellow in the National Institute for Basic Biology, Okazaki, Japan.
  • 1995-1996: COE visiting Professor in National Institute for Basic Biology, Okazaki, Japan.
  • 1991-1995: Lecturer at Center for Biosciences, Jamia Millia University, New Delhi.
  • 1992: Ph.D. Bioscience from Jamia Millia University, Delhi, India. (Subject: Mechanism of stress tolerance).
  • 1989: M.Sc. Biosciences from Jamia Millia University, Delhi, India (first position in University).
  • 1988: B.Ed. Education from Jamia Millia University, Delhi, India (first position in University).
  • 1986: B.Sc. Life Sciences from University of Delhi, New Delhi, India.

Scientific honours (Awards) received

  • Alzheimer Forschung Initiative grant award (2013).
  • FOM/ALW open competition grant award (2011).
  • Internationale stichting Alzheimer onderzoek grant award (2007).
  • C.J. Kok Prize for the discovery of the year 2003 from Faculty of Mathematics and Natural Sciences, University of Leiden (2004).
  • Japan Society for Promotion of Science fellowship award (1996).
  • A center-of-excellence grant award from the Monbusho, Japan (1995).
  • Young scientist award, Department of Science & Technology (DST), Govt. of India (1993).
  • Joint CSIR-UGC research fellowship & lecturership award (1989).
  • Award of merit for getting first position in University in M.Sc. (1989).
  • Award of merit for getting first position in University in B.Ed. (1988).

Grants received

  • Project grant sanctioned by Alzheimer Forschung Initiative (AFI), for 2 years in 2013-2015. (Research Topic: In vivo MRI studies in assessment of sex-related metabolic changes in AD (PI) (€ 76.500).
  • Project grant sanctioned by „The Netherlands Organization for Scientific Research (NWO)“ within open competition from the division FOM/ALW for 5 years in 2011. (Research topic: Phenotypic engineering) (PI) (€743.000).
  • Project grant sanctioned by Centre for Medical System Biology (CMSB), one of the four Genomic Centres of Excellence of the Netherlands Genomics Initiative (NGI) for 4 years (2008). (Research Topic: Prediciting Alzheimer’s disease: diagnosis and prognosis) (PI) (€ 60.000).
  • Project grant sanctioned by Internationale Stichting Alzheimer Onderzoek (ISAO), for 3 years in 2007. (Research Topic: In vivo mMRI and MRS studies in assessment of early biomarkers of AD) (PI) (€ 72.000).
  • Research fellowship grant awarded by Japan Society for Promotion of Science (JSPS), Japan (1996). (Research Topic: Stress tolerance by engineering glycinebetaine biosynthetic pathway).
  • A center-of-excellence research grant awarded by the Monbusho, Japan (1995). (Research Topic: Enhanced stress tolerance of Arabidopsis by expressing choline oxidase for betaine synthesis).
  • Project grant sanctioned by Research Institute of Innovative Technology for the Earth (RITE), Japan, for 2 years in 1993. (Research Topic: Micropropagation of fast growing species with high CO2 assimilating potential) (co-PI with Prof. P. Pardha Saradhi and K.G. Mukerji).
  • Young Scientist Project grant sanctioned by the Department of Science and Technology (DST), Govt. of India (India) for 2+1 years in 1993. (Research Topic: Molecular mechanism of proline induce stress tolerance) (PI)..

Personal Activities

  • European Science Foundation Pool of Reviewers, 2012.
  • Editorial board member of the Journal: ISRN Biomedical Imaging (Hindawi Pub.)
  • Scientific co-organiser of Lorentz workshop „Hacking the biological clock“ (Leiden, The Netherlands, April 10-13, 2012).
  • Guest Editor for special issues in the journal „Current Medical Imaging Reviews“ (Bentham Science Publishers) on „Prospects of magnetic resonance imaging for Alzheimer’s disease“ (Issue February 2011).
  • Guest Editor for special educational issue in „Photosynthetic Research“ (Springer) on „Basics and application of biophysical techniques in photosynthesis“ (Issues: September 2009 and November 2009).
  • Frequent reviewer of: (a) grant proposal NWO/CW ECHO grants; (b) Alzheimer’s association grants; (c) ERC grants.
  • Frequent reviewer for journals: Brain, Neuroimage, Neuroscience Letters, Current Medical Imaging Reviews, Free Radicals in Medicine, Photosynthesis research, Journal of Magnetic Resonance Imaging.
  • Served as member of faculty for the ISN/ESN summer school „Advance Imaging and Biomarkers in Neurological Disorders“, Meißen, Germany (July 6-10, 2009).
  • Scientific organiser of CMSB mini-symposium „Alzheimer’s disease: from biomarkers to common denominators“ (Oegstgeest, The Netherlands, April 2006)
  • Member of Ph.D. thesis promotion/opposition committee at Leiden University for 8 Ph.D. students (since 2006).
  • Supervision/co-promotor of 5 Ph.D. projects at Leiden University, Leiden, The Netherlands, since 2004.
  • Honorary lecturer at the Center for Biosciences, Jamia Millia University, New Delhi, India (during academic session 1994-95).
  • Subject expert for making TV programs on „plasma membrane“ for UGC Educational Telecast (1993-95). 

Memberships

  • Member of „International Society for Magnetic Resonance in Medicine (ISMRM)“ since 2006.
  • Member of „European Society for Magnetic Resonance in Medicine and Biology (ESMRMB)“ since 2013.
  • Member of „International Society to Advance Alzheimer Research and Treatment (ISTAART)“ since 2008.
  • Member of „Alzheimer Research Forum“ since 2005.

Publications

Journal Articles

141. Singer R., Oganezova I, Hu W., Ding Y., Papaioannou A., de Groot H.J.M., Spaink, SP., Alia A. Unveiling the Exquisite Microstructural Details in Zebrafish Brain Non-Invasively Using Magnetic Resonance Imaging at 28.2 T. Molecules, 29, 4637 (2024) [DOI;PubMed]

140.Bashirova, N., Butenschön, E., Poppitz, D., Gaß, H., Halik, M., Dentel, D., Tegenkamp, C., Matysik, J., Alia, A. Magnetic Resonance Imaging-Based Monitoring of the Accumulation of Polyethylene Terephthalate Nanoplastics. Molecules 29(18) (2024) 4380. [DOI; PubMed] 

139. Singer, R., Oganezova, I., Hu, W., Liu, L., Ding, Y., Groot, H.J. M. de, Spaink, H.P., Alia, A. Ultrahigh field diffusion magnetic resonance imaging uncovers intriguing microstructural changes in the adult zebrafish brain caused by Toll-like receptor 2 genomic deletion. NMR Biomed (2024) e5170. [DOI; PubMed] 

138. Annunziato, M., Bashirova, N., Eeza, M.N. H., Lawson, A., Fernandez-Lima, F., Tose, L.V., Matysik, J., Alia, A., Berry, J.P. An Integrated Metabolomics-Based Model, and Identification of Potential Biomarkers, of Perfluorooctane Sulfonic Acid Toxicity in Zebrafish Embryos. Environ Toxicol Chem (2024). [DOI; PubMed]An Integrated Metabolomics-Based Model, and Identification of Potential Biomarkers, of Perfluorooctane Sulfonic Acid Toxicity in Zebrafish Embryos. Environ Toxicol Chem (2024). [DOI; PubMed]

137. Kim, Y., Alia, A., Kurle-Tucholski, P., Wiebeler, C., Matysik, J. Electronic Structures of Radical-Pair-Forming Cofactors in a Heliobacterial Reaction Center. Molecules 29(5) (2024). [DOI; PubMed] Alia, A., Kurle-Tucholski, P., Wiebeler, C., Matysik, J. Electronic Structures of Radical-Pair-Forming Cofactors in a Heliobacterial Reaction Center. Molecules 29(5) (2024). [DOI; PubMed] 

136. Annunziato,M.,Bashirova,N., Eeza,M.N.H., Lawson,A., Benetti,D., Stieglitz, J.D., Matysik, J., Alia,A., Berry, J.B. High-Resolution Magic Angle Spinning (HRMAS) NMR Identifies Oxidative Stress and Impairment of Energy Metabolism by Zearalenone in   Embryonic Stages of Zebrafish (Danio rerio), Olive Flounder (Paralichthys olivaceus) and Yellowtail Snapper (Ocyurus chrysurus)Toxins 2023, 15(6), 397 [DOI;PubMed]

135. Eeza,M.N.H., Singer, R., Ding, Y., He, J., Zuberi, Z., Baelde, H.J., de Groot,H.J.M., Matysik,J., Spaink,H.P., Alia A. Probing microstructural changes in muscles of leptin-deficient zebrafish by non-invasive ex-vivo magnetic resonance microimaging. PLoS One. 18 (2023):e0284215. [DOI;PubMed]

134. Hu, W., Liu,L., Forn-Cuni,G., Ding,Y., Alia,A., Spaink,H.P. Transcriptomic and Metabolomic Studies Reveal That Toll-like Receptor 2 Has a Role in Glucose-Related Metabolism in Unchallenged Zebrafish Larvae (Danio rerio).Biology 12 (2023) 323 DOI;PubMed]

133.  Bashirova,N.,Poppitz,D.,Klüver,N., Scholz,S., Matysik,J., Alia,A. A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo. Sci Rep. 13 (2023)[DOI;PubMed]

132. Matysik, J., Kim, Y., Kurle-Tucholski, P., Musabirova, G., Qin, R., Alia, A. Integrated Structural Biology. In: Polenova,T., Quinn, C.M., Gronenborn, A.M. (Eds.) Royal Society of Chemistry 30 (2023) 301-326. [DOI;PubMed] ISBN: 978-1-83916-183-4.

131.   Matysik J., Song C., Bielytskyi P., Alia A. Teaching product operators using the Vega diagram. Solid state Nuclear Magnetic Resonance 122 (2022) 101830. [DOI; PubMed]

130.   Eeza M.N.H., Bashirova N., Zuberi Z., Matysik J., Berry J.P., Alia A. An integrated systems level model of ochratoxin A toxicity in the zebrafish (Danio rerio) embryo based on NMR metabolic profiling. Scientific Reports 12 (2022) 6341. [DOI;PubMed]

129.   Singer, R., Alia, A. Evaluation of suprachiasmatic nucleus in Alzheimer’s disease with non-invasive magnetic resonance methods. Neur. Reg. Res. 17 (2022) 1753-1754. [DOI; PubMed]

128.   Kettwig, M., Ternka, K.,  Wendland, K., Krüger, D., Zampar, S., Schob, C., Franz, J., Aich, A., Winkler, A., Sadman, S., Kaurani, L., Epple, R., Werner, H., Hakroush, S., Kitz, J., Prinz, M., Bartok, E., Hartmann, G., Schröder, S., Rehling, P., Henneke, M., Boretius, S., Alia, A., Wirths, O., Fischer, A., Stadelmann, C., Nessler, S., and Gartner, J. Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy. Nat. Commun. 12 (2021) 6530. [DOI;PubMed]

127. Matysik, J., Ding, Y., Kim, Y., Kurle, P., Yurkovskaya, A., Ivanov, K., Alia, A. Photo-CIDNP in solid state. Appl. Magn. Reson. 52 (2021) 521 – 537. [DOI; PubMed]

126.   Annunziato, M., Eeza, M.N.H., Bashirova, N., Lawson, A., Matysik, J., Benetti, D., Grosell, M., Stieglitz, J.D., Alia, A., Berry, J.P. An integrated systems-level model of the toxicity of brevetoxin based on high-resolution magic-angle spinning nuclear magnetic resonance (HRMAS NMR) metabolic profiling of zebrafish embryos. Sci. Tot. Env. 803 (2021) e149858. [DOI; PubMed]

125. Ding, Y., Haks, M.C., Forn-Cuní, G., He, J., Nowik, N., Harms, A.C., Hankemeier, T., Eeza, M.N.H., Matysik, J., Alia, A., Spaink, H.P. Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways. Cell Biosci. 11 (2021) 126. [DOI; PubMed]

124. He, J., Ding, Y., Nowik, N., Jager, C., Hashem Eeza, M.N., Alia, A., Baelde, H.J., Spaink, H.P. Leptin deficiency affects glucose homeostasis and results in adiposity in zebrafish. J Endocrinol. 249 (2021) 125-134. [DOI; PubMed]

123. Eeza, M.N.H., Singer, R., Höfling, C., Matysik, J., de Groot, H.J.M., Roßner, S., Alia, A. Metbolic profiling of suprachiasmatic nucleus reveals multifaceted effects in an Alzheimer’s disease mouse model. J Alzheimer’s Disease 81 (2021) 797-808. [DOI; PubMed]

122.  Augustijn, D., de Groot, HJM.,  Alia A.  HR-MAS NMR Applications in Plant Metabolomics. Molecules 26 (2021) 931. [DOI;PubMed]

121.  van Schadewijk, R., Krug, J.R., Webb, A., Van As, H., Velders, A.H., de Groot, H.J.M., Alia, A. MRM microcoil Performance calibration and usage demonstrated on Medicago truncatula roots at 22 T. Jove 167 (2021) e61266 1-20. [DOI;PubMed]

120.  Janssen, G.J., Eschenbach, P., Kurle, P., Bode, B.E., Neugebauer, J., de Groot, H.J.M., Matysik, J., Alia, A. Analysis of the electronic asymmetry of the Primary electron donor of photosysetm I of Spirodela oligorrhiza by photo-CIDNP solid-state NMR. Magn. Seson.1 (2020) 261-274. [DOI]

119. Ding, Y., Raterink, R:J:, Marín-Juez-, R., Veneman, W.J., Egbers, K., van den Eeden, S., Haks, M.C., Joosten, S.A., Ottenzoff, T.H.M., Harms, A.C., Alia, A., Hankemeier, T., Spaink, H.P. Tuberculosis causes highly conserved metabolic changes in human patients, mycobacteria-infected mice and zebrafish larvae. Scientific Reports 10 (2020) 11635. [DOI];PubMed]

118. Krug, J.R., van Schadewijk, R., Vergeldt, F.J., Webb, A.G., de Groot, H.J.M., Alia, A., van As, H., Velders, A.H. Assessing spatial resolution, ascquisition time and signal-to-noise ratio for commericial microimaging systems at 14.1, 17.6 and 22.3 T. J. Magn. Res. 316 (2020) 106770. [DOI]

117. Gebreab, K.Y., Eeza, M.N.H, Bai, T., Zuberi, Z., Matysik, J., O’Shea, K.E., Alia, A., Berry, J.P. Comparative toxicometabolomics of perfluorooctanoic acid (PFOA) and next-generation perfluoroalkyl substances. Environmental Pollution 265 (2020) 114928. [DOI]

116. Rößler, T., Alia, A., Heimann, R. Einblick in die Erforschung von Alzheimer – Eine fächerübergreifende Unterrichtseinheit. Chemkon 27 (2020) 13-21. [DOI]

115. von Schadewijk, R., Krug, J.Rl, Shen, D., Gupta, K.B.S.S., Vergeldt, F.J., Bisseling, T., Webb, A.,G. van As, H., Velders, A.H., de Groot, H.J.M, Alia, A. Magnetic resonance microscopy at cellular resolution and localised spectroscopy of medicago trucatula at 22.3 Tesla. Scientific Reports 10 (2020) 971. [DOI;PubMed]

114. Pérez-Rius, C., Folgueira, M., Elorza-Vidal, X., Alia, A., Hoegg-Beiler, M.B., Eeza, M.H.B., Luz, M., Nunes, V., Barrallo-Gimeno, A., Estevez, R. Comparison of zebrafish and mice knockouts for megalencephalic leukoencephalopathy proteins indicates that GlialCAM/MLC1 forms a functional unit. Orphanet J. Rare Dis. 14 (2019) 268. [DOI, PubMed] 

113. Paul, S., Roy U., Böckers, M., Neugebauer,, J., Alia, A., and Matysik, J. 15N photo-CIDNP MAS NMR analysis of a bacterial photosynthetic reaction center of rhodobacter sphaeroides wildtype. J. Chem. Phys. 151 (2019) 195101. [DOI]

112. Gräsing, D., Dziubinska-Kühn, K.M., Zahn, S., Alia, A., Matysik, J. Studying hydrogen bonding and dynamics of the acetylate groups of the special pair of Rhodobacter sphaeroides WT. Scientific Reports 9 (2019) e10528. [DOI]

111. Augustijn, D., de Groot, H.J.M., Alia, A. A robust circadian rhythm of metabolites in arabidopsis thaliana mutants with enhanced growth characteristics. PLOS One 14 (2019), e0218219. [DOI]

110. Zuberi, Z., Eeza, M.N.H., Matysik, J., Berry, J.P., Alia, A. NMR-based metabolic profiles of intact zebrafish embryos exposed to aflatoxin B1 recapitulates hepatotoxicity and supports possible neurotoxicity. Toxins 11 (2019) 258. [DOI]

109. Bielytskyi, P., Gräsing, D., Zahn, S., Alia, A., Matysik, J. 15N-1H Transfer of light-induced nuclear hyperpolarization in frozen photosynthetic reaction centers. Appl. Magn. Res. 50 (2019) 695-708. [DOI]

108. Roy, U., Heredia-Munoz, M.T., Stute, L., Höfling, C., Matysik, J., Meijer, J.H., Roßner, S., Alia, A. Degeneration of the suprachiasmatic nucleus in an Alzheimer’s disease mouse model monitored by in vivo magnetic resonance relaxation measurements and immunohistochemistry. Journal of Alzheimer’s Disease 69 (2019) 363-375. [DOI; PubMed]

107. Zill, J.C., Kansy, M., Goss, R., Alia, A., Wilhelm, C., Matysik, J. 15N photo-CIDNP MAS NMR on both photosystems and magnetic field dependent 13C photo-CIDNP MAS NMR in photosystem II of the diatom phaeodactylum tricornutum. Photosynthetic Research 140 (2019) 151-171. [DOI]; PubMed]

106. Alia, A., Roßner, S. Gender, GABAergic dysfuncion and AD. Aging 10 (2018) 3636-3637. [DOI]

105. Bielytskyi, P., Gräsing, D., Zahn, S., Mote, R.K., Alia, A., Madhu, P.K., Matysik, J. Assignment of NMR resonances of protons covalently bound to photochemically active cofactors in photosynthetic reaction centers by 13C-1H photo-CIDNP MAS-J-HMQC experiment. J. Magn. Res. 298 (2018) 64-76.  [DOI; PubMed]

104. Augustijn, D., van Tol, N., van der Zall, B.J., de Groot, H.J.M., Alia, A. High-Resolution Magic angle Spinning NMR studies for metabolic characterization of arabidopsis thaliana mutants with enhanced growth characteristics. PLOS One 13 (2018) e0209695. [DOI]

103. Janssen G, Bielytskyi P, Artiukhin D, Neugebauer J, de Groot HJM, Matysik J, and Alia A. Photochemically induced dynamic nuclear polarization NMR on photosystem II: donor cofactor observed in entire plant. Scientific Reports 8 (2018) e17853. [DOI]

102. Bielytsky, P., Gräsing, D., Mote, K.R., Gupta, S.S. Vega, S., Madhu, P.K., Alia, A., Matysik, J. 13C-1H Transfer of light-induced hyperpolarization allows for selective detection of Protons in frozen photosynthetic reaction Center. J. Magn. Reson. 293 (2018) 82-91. [PubMed; DOI]

101. Van Schadewijk, R., van den Berg, T.E., Sai Sankar Gupta, K.B., Ronen, I, de Groot, H.J.M, Alia, A. Non-invasive magnetic resonance imaging of oils in botryococcus braunii green algae: chemical shift-selective and diffusion-weighted imaging. Plos One 13 (2018) e0203217. [DOI; PubMed]

100.    Zill, J.C., He, Z., Tank, M., Ferlez, B.H., Canniffe, D.P., Lahav, Y, Bellstedt, P., Alia, A., Schapiro, I., Golbeck, J.H., Bryant, D.A., Matysik, J. 15N photo-CIDNP MAS NMR analysis of reaction centers of Chloracidobacterium thermophilum. Phytosynth. Res. 137 (2018) 295-305. [DOI]

99.    35.  Flemmig, J., Zámocký, M., Alia, A. Amyloid ß and free heme: bloody new insights into the pathogenesis of Alzheimer’s disease. Neural Reg. Res. 13 (2018) 1170-1174. [DOI]

98.    Roy, U., Stute, L., Höfling, C., Hartlage-Rübsamen, M., Matysik, J., Rossner, S., Alia, A. Sex and Age specific Modulation of brain GABA Levels in a mouse model of Alzheimer’s disease. Neurobiology of Aging 62 (2018) 168-179. [DOI]

97.    Najdanova,  M., Gräsing, D., Alia A, Matysik, J. Analysis of the electronic structure of the special pair of a bacterial photosynthetic reaction center by 13C photochemically induced dynamic nuclear polarization magic-angle spinning NMR using a double-quantum axis. Photochem Photobiol 94 (2018) 69-80. [DOI]

96.    Roy, U., Conklin, L., Schiller, J., Matysik, J., Berry, J.P., Alia, A. Metabolic profiling of zebrafish embryos by NMR spectroscopy reveals multifaceted neurotoxicity of beta-methylamino-L-alanine (BMAA). Scientific Reports 7 (2017) e17305. [DOI]

95.    Chiziane, E., Telemann, H., Krueger, M., Adler, J., Arnhold, J., Alia, A., Flemmig, J. Free heme and amyloid beta: A fatal Liaison at Alzheimer’s Disease. Journal of Alzheimer’s Disease 61 (2017) 963-984. [DOI]

94.    Gräsing, D., Bielytskyi, P., Cépedes-Camacho, I.F., Alia, A., Marquardsen, T., Engelke, F., Matysik, J. Field-cycling NMR with high-Resolution detection under Magic-angle Spinning: Determination of field-window for nuclear hyperpolarization in a photosynthetic reaction Center. Scientific Reports 7 (2017) e12111. [DOI]

93.    van Tol, N., Rolloos, M., Augustijn, D., Alia A, de Groot, H.J., Hooykaas, P.J.J., van der Zaal, B.J. An arabidopsis mutant with high operating efficiency of phytotsystem II and low chlorophyll fluorescence. Scientific Reports 7 (2017) e3314. [DOI]

92.    Zill, J.C., Kansy, M., Goss, R., Köhler, L., Alia A, Wilhelm, C., Matysik, J. Photo-CIDNP in the reaction center of the diatom Cyclotella meneghiniana observed by 13C MAS NMR. Zeitschrift für Physikalische Chemie – International Jourmal of Research in Physical Chemistry and Chemical Physics 231 (2016) 347-367.

91.    Augustijn, U., Roy, U., van Schadewijk, R., de Groot, H.J.M., Alia A. Metabolic profiling of intact arabidopsis thaliana leaves during circadian cycle using 1H high resolution magic angle spinning NMR. Plos One 11 (2016) e0163258.

90.  Berry JP, Roy U, Jaja-Chimedza A, Sanchez K, Matysik J, Alia A. High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance of Intact Zebrafish Embryos Detects Metabolic Changes Following Exposure to Teratogenic Polymethoxyalkenes from Algae.  Zebrafish 13 (2016) 456-465.

89.   Wang XJ, Thamarath SS, Alia A, Bode BE, Matysik J. The solid-state photo-CIDNP effect. Acta Phys. Chim. Sin. 32 (2016) 399-404.

88.   Najdanova M, Janssen GJ, de Groot HJM, Matysik J. Alia A. Analysis of electron donors in photosystems in oxygenic photosynthesis by Photo-CIDNP MAS NMR. Journal of Photochemistry and Photobiology B: Biology. 152 (2015) 261-271.

87.    Paul, S., Bode B, Matysik J, Alia A. Photochemically induced dynamic nuclear polarization observed by solid-state NMR in a uniformly 13C-isotope-labelled photosynthetic reaction center. J. Phys. Chem. 119 (2015) 13897-13903.

86.    Kara F, Höfling C, Roßner S, Schliebs R, Van der Linden A, Groot HJM and Alia A. In vivo longitudinal monitoring of changes in the corpus callosum integrity during disease progression in a mouse model of Alzheimer’s disease. Current Alzheimer Research 12 (2015) 941-950.

85.   Chatzopoulou A, Roy U, Meijer A, Alia A, Spaink HP, Schaaf MJM. Transcriptional and metabolic effects of glucocorticoid receptor alpha and beta signaling in zebrafish. Endocrinology 156 (2015) 1757-1569.

84.    Alia A, van Duijn S, Kara F, van Buchem M. Direct in vivo  assessment of sex-related metabolic differences in a mouse model of Alzheimer’s disease by MRI. Alzheimer’s & Dementia 10 (2014) 826.

83.  Sai Sankar Gupta KB, Daviso E, Jeschke G, Alia A, Ernst M, Matysik J. Spectral editing through laser-flash excitation in two-dimensional photo-CIDP MAS NMR experiments. J. Mag. Res. 246 (2014) 9-17.

82.  Sirisi S, Folgueira M, López-Hernández T, Minieri L, Pérez-Rius C, Gaitán-Peñas H, Zang J, Martinez A, Capdevilla-Nortes X, De La Villa P, Roy U, Alia A, Neuhauss S, Ferroni S, Nunes V, Estévez R, Barrallo-Gimeno A. Megalencephalic leukoencephalophathy with subcortical cysts protein 1 regulates glial surface localization of GLIALCAM from fish to humans. Hum. Mol. Genet. 23 (2014) 5069-5086.

81.  van Amerongen, Y.F., Roy, U., Spaink, H.P., de Groot, H.J.M.,Huster, D, Schiller, J., Alia A, A. Zebrafish brain lipid characterization and quantification by 1H nuclear magnetic resonance spectroscopy and MALDI-TOF mass spectrometry. Zebrafish 11 (2014) 240-247. 

80.   Van Duijn S, Nabuurs RJA, van Duinen SG, Natté R, van Buchem MA, Alia A A. Longitudinal monitoring of sex related in vivo metabolic changes in the brain of AD transgenic mouse using magnetic resonance spectroscopy. J. Alzheimer’s Disease 34 (2013) 1051-1059.

79.    Alia A, Buda F, de Groot HJM, Matysik J. Solid-State NMR of Nanomachines Involved in Photosynthetic Energy Conversion. Ann. Rev. Biophys. 42 (2013) 675-699.

78.   Kara F, Chen F, Ronen I, de Groot HJM, Matysik J, Alia A. In vivo measurement of transverse relaxation time in the mouse brain at 17.6T. Mag. Res.Med. 70 (2013) 985-993.

77.   Sai Sankar Gupta KB, Alia A, de Groot HJ, Matysik J,  Symmetry break of special pair: photochemically induced dynamic nuclear polarization NMR confirms control by nonaromatic substituents,  J. Am. Chem. Soc. 135 (2013) 10382-10387.

76.   Surendran Thamarath S, Alia A, Roy E, Sai Sankar Gupta KB, Golbeck JH, Matysik J,  The field-dependence of the solid-state photo-CIDNP effect in two states of heliobacterial reaction centers,  Photosynthesis Research 117 (2013) 461-469.

75.   Sai Sankar Gupta KB, Alia A, Buda F, de Groot HJM, Matysik J. „Bacteriopheophytin a in the active branch of the reaction center of  Rhodobacter sphaeroides is not disturbed by the matrix as shown by 13C photo-CIDNP MAS NMR“. J. Phys. Chem. B, 117 (2013) 3287-3297.

74.   Kara F, van Dongen ES, Schliebs R, Van Buchem MA, de Groot HJM, Alia A . Monitoring blood flow alterations in the Tg2576 mouse model of Alzheimer’s disease by in vivo magnetic resonance angiography at 17.6 T. NeuroImage 60 (2012) 958-966.

73.   Ramirez IB, Pietka G, Jones DR, Divecha N, Alia A A, Baraban SC, Hurlstone AF, Lowe M. Impaired neural development in a zebrafish model for Lowe syndrome. Human Molecular Genetics 21 (2012) 1744-59.

72.   Bode BE, Thamarath SS, Gupta KBSS, Alia A, Jeschke G, Matysik J.  The Solid-state photo-CIDNP effect and its analytical application : Photo-CIDNP MAS NMR to Study Radical Pairs. Topics in Current Chemistry 338 (2012) 105-121.

71.   Janssen GJ, Roy E, Matysik J, Alia A. 15N Photo-CIDNP MAS NMR To Reveal Functional Heterogeneity in Electron Donor of Different Plant Organisms. Applied Magnetic Resonance 42 (2012) 57-67.

70.  Thamarath SS, Alia A, Daviso E, Mance D, Golbeck JH, Matysik J. Whole cell nuclear magnetic resonance characterization of two photochemically active states of the photosynthetic reaction center in heliobacteria. Biochemistry 51  (2012) 5763–5773.

69.   Vermeij W, Florea B, Isenia S, Alia A, Brouwer J, Backendorf C. Proteomic identification of in vivo interactors reveals novel function of skin cornification proteins. Journal of Proteome Research 11 (2012) 3068-3076.

68.   Thamarath SS, Bode BE, Prakash S, Gupta KBSS, Alia A A., Jeschke G, Matysik J.  Electron Spin Density Distribution in the Special Pair Triplet of Rhodobacter sphaeroides R26 Revealed by Magnetic Field Dependence of the Solid-State Photo-CIDNP Effect. J. Am. Chem. Soc. 134 (2012) 5921-5930. 

67.   Haud N, Kara F, Diekmann S, Henneke, M, Willer J, Hillwig MH, Gregg RB, MacIntosh GC, Gartner J, Alia A, Hurlstone AFL. RNase T2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA.  Proc. Natl. Acad. Sci. USA 108 (2011) 1099-1103.

66.    Daviso E, Janssen, GJ, Alia A, Jeschke G, Matysik J, Tessari M. A 10 000-fold Nuclear Hyperpolarization of a Membrane Protein in the Liquid Phase via Solid-State Mechanism. J. Am. Chem. Soc. 133 (2011) 16754-16757.

65.   Kara F, Braakman N, van Buchem MA, de Groot HJ, Alia A A. Prospects of magnetic resonance spectroscopy in mouse models of Alzheimer’s disease. Curr. Med. Imag. Rev. 7 (2011) 80-87.

64.    Alia A, Buchem MA Prospects of magnetic resonance imaging for Alzheimer’s disease (Editorial). Curr. Med. Imag. Rev. 7 (2011) 1-2.

63.    Vermeij WP, Alia A, Backendorf C., ROS Quenching potential of the epidermal cornified cell envelope. Journal of Investigative Dermatology 131 (2011) 1435–1441.

62.    Ali S, Champagne DL, Alia A, Richardson MK. Large-scale analysis of acute ethanol exposure in zebrafish development: A critical time window and resilience. PloS one 6  (2010) 20037.

61.    Kabli S, He SN, Spaink HP, Hurlstone A, Jagalska ES, De Groot HJM, Alia A. In Vivo Magnetic Resonance Imaging to Detect Malignant Melanoma in Adult Zebrafish. Zebrafish. 7 (2010) 143-148.

60.   Henneke M, Diekmann S, Haud N, Alia A, Hurlstone AFL, Gartner J.  RNASET2-deficient cystic leukoencephalopathy is a new lysosomal disorder. J. Inher. metabol. Diseas. 33 (2010) S127-S127.

59.    Janssen GJ, Daviso E, van Son, M, de Groot HJ, Alia A A, Matysik J. Observation of the solid-state photo-CIDNP effect in entire cells of cyanobacteria Synechocystis, Photosynth Res. 104 (2010) 275-282.

58.   Daviso E, Diller A, Gast P, Alia A, Lugtenburg J, Muller M, Matysik J. Action Spectroscopy on Dense Samples of Photosynthetic Reaction Centers of Rhodobacter sphaeroides WT Based on Nanosecond Laser-Flash 13C Photo-CIDNP MAS NMR. Appl. Magn. Reson. 38 (2010) 105-116.

57.   Daviso E, Prakash S, Alia A, Gast P, Jeschke G, Matysik J. Nanosecond-flash 15N photo-CIDNP MAS NMR on reaction centers of Rhodobacter sphaeroides R26.  Appl. Magn. Reson. 37 (2010) 49-63.

56.   Daviso E, Prakash S, Alia A, Gast P, Neugebauer J, Jeschke G, Matysik J.  The electronic structure of the primary electron donor of purple bacteria at atomic resolution as observed by photo-CIDNP 13C MAS NMR. Proc. Natl. Acad. Sci. USA. 106 (2009) 22281-22286.

55.   Matysik J, Diller A, Roy E, Alia A. The solid-state photo-CIDNP effect. Photosynth. Res. 102 (2009) 427-435.

54.  Alia A A, Ganapathy S, de Groot HJM. Magic Angle Spinning (MAS) NMR: a new tool to study the spatial and electronic structure of photosynthetic complexes. Photosynth. Res. 102 (2009) 415-425.

53.  Messinger J, Alia A, A, Govindjee. Basics and application of biophysical techniques in photosynthesis and related processes, Part 1. Photosynth. Res. 101 (2009) 89-92.

52.  Messinger J, Alia A. Govindjee. Basics and application of biophysical techniques in photosynthesis and related processes, Part2. Photosynth. Res. 102 (2009) 103-106.

51.   Muskulus M, Scheenstra AEH, Braakman N, Dijkstra J, Verduyn-Lunell S, Alia A, de Groot HJM, Reiber J HC. Prospects for early detection of Alzheimer’s disease from serial MR images in transgenic mouse models. Curr. Alzheimer Res. 6 (2009) 503-518.

50.   Alia A, Wawrzyniak P, Janssen G, Buda F, Matysik J, de Groot H. Differential charge polarization of axial histidines in bacterial reaction centres balances the asymmetry of the special pair. J. Am. Chem. Soc. 131  (2009) 9626-9627.

49.  Daviso E, Alia A, Prakash S, Diller A, Gast P, Lugtenburg J, Matysik J, Jeschke G. Electron-nuclear spin dynamics in a bacterial photosynthetic reaction center. J. Phys. Chem. C, 113 (2009) 10269-10278.

48.   Braakman N, van Buchem MA, Schliebs R, de Groot HJM, Alia A. Recent advances in visualizing Alzheimer’s plaques by in vivo magnetic resonance imaging. Curr. Med. Imag. Rev. 5: 2-9 (2009). 

47.   Kabli S, Spaink HP, De Groot HJ, Alia A. In vivo metabolite profile of adult zebrafish brain obtained by high resolution localized magnetic resonance spectroscopy. J. Mag. Res. Imag. 29:275-281 (2009).

46.  Kara F, Ravensbergen J. Braakman N, van Buchem MA, de Groot HJM, Schliebs R, Alia A, In vivo evaluation of cerebrovascular blood flow artifacts in a transgenic mouse model of Alzheimer’s disease using MRI. Journal of Neurochemistry 110 (2009) 38.

45.  Wawrzyniak PK, Alia A, Schaap RG, Heemskerk MM, de Groot HJM, Buda F. Protein-induced geometric constraints and charge transfer in bacteriochlorophyll-histidine complexes in LH2. Phys. Chem. Chem. Phys. 10 (2008) 6971-6978.

44.  Braakman N, Oerther T, de Groot HJM, Alia A. High resolution localized two-dimensional MR spectroscopy in mouse brain in vivo.  Mag. Res.Med. 60 (2008) 449-456. 

43.   Daviso E, Diller A, Alia A, Matysik J, Jeschke G. Photo-CIDNP MAS NMR beyond the T1 limit by fast cycles of polarization extinction and polarization generation. J. Mag. Res. 190 (2008) 43-51. 

42.  Roy E, Rohmer T, Gast P, Jeschke G, Alia A, Matysik J. Characterization of the primary radical pair in reaction centers of Heliobacillus mobilis by 13C photo-CIDNP MAS NMR. Biochemistry 47 (2008) 4629-4635.

41.  Diller A, Roy E, Gast P, van Gorkom HJ, de Groot HJM, Glaubitz C, Jeschke G, Matysik J, Alia A. 15N photochemically induced dynamic nuclear polarization magic-angle spinning NMR analysis of the electron donor of photosystem II. Proc. Nat. Acad. Sci. (USA) 104 (2007) 12767-12771. 

40.  Diller A, Prakash S, Alia A, Gast P, Matysik J, Jeschke G. Signals in solid-state photochemically induced dynamic nuclear polarization recover faster than signals obtained with the longitudinal relaxation time.  J. Phys. Chem. B, 111 (2007) 10606-14. 

39.  Roy E, Alia A, Gast P, van Gorkom H, de Groot HJM, Jeschke G, Matysik J. Photochemically induced dynamic nuclear polarization in the reaction center of the green sulphur bacterium Chlorobium tepidum observed by C-13 MAS NMR. Biochim. Biophys. Act. (Bioenergetics) 1767 (2007) 610-615. 

38.  Prakash S, Alia A, Gast P, de Groot HJM, Jeschke G, Matysik J. 13C chemical shift map of the active cofactors in photosynthetic reaction centers of Rhodobacter sphaeroides revealed by photo-CIDNP MAS NMR. Biochemistry 46 (2007) 8953-8960. 

37.  Roy E, Diller Alia A, Gast P, van Gorkom HJ, de Groot HJM, Jeschke G. Matysik J. Magnetic field dependence of C-13 photo-CIDNP MAS NMR in plant photosystems I and II,  Applied Mag. Reson. 31 (2007) 193-204.

36.   Braakman N, Matysik J, van Duinen SG, Schliebs R, de Groot HJM, and Alia A. Longitudinal Assessment of Alzheimers β-amyloid plaque Development in Transgenic Mice Monitored by In Vivo Magnetic Resonance Microimaging. J. Magn. Reson. Imaging. 24 (2006) 530-536.

35.  Kabi S, Alia A, Spaink HP, Verbeek FJ, de Groot HJM. Magnetic resonance Microscopy of adult zebrafish. Zebrafish (2006) 431-439.

34.  Braakman N, Matysik J, de Groot HJM, Schliebs R, Alia A A. Alzheimer’s b-amyloid plaque development monitored by invivo magnetic resonance microscopy. Int. J. Devl Neuroscience 24 (2006) 226.

33.  Prakash S, Alia A, Gast P, de Groot HJ.M, Jeschke G, Matysik J. Magnetic field dependence of photo-CIDNP MAS NMR on photosynthetic reaction centres of Rhodobacter sphaeroides WT. J. Am. Chem. Soc. 127 (2005) 14290-14298.

32.  Diller A, Alia A, Roy E, Gast P, van Gorkom HJ, Zaanen J, de Groot HJM, Glaubitz C, Matysik J. Photo-CIDNP solid-state NMR on photosystems I and II: What makes P680 special? Photosynth. Res. 84 (2005) 303-308.

31.  Alia A., Roy E, Gast P, van Gorkom HJ, de Groot HJM, Jeschke G, Matysik J. .Photochemically induced dynamic nuclear polarisation in photosystem I of plants observed by 13C magic angle spinning NMR. J. Am. Chem. Soc126(2004) 12819-12826.

30.   Alia A, Matysik J, de Boer I, Gast P, van Gorkom HJ, de Groot HJM.  Heteronuclear 2D (H-1-C-13) MAS NMR resolves the electronic structure of coordinated histidines in light-harvesting complex II: Assessment of charge transfer and electronic delocalization effect. J. Biomol. NMR  28 (2004) 157-164.

29.   Prakash S, Alia A, Gast P, Jeschke G, de Groot HJM, Matysik J.  Photochemically induced dynamic nuclear polarisation in entire bacterial photosynthetic units observed by 13C magic-angle spinning NMR.  J. Mol. Struct. 661 (2003) 625-633.

28.   Alia A, Hulsebosch B, van Gorkom HJ, Raap J, Lugtenburg J, Matysik J, de Groot HJM, and Gast P.
Probing the electronic structure of tyrosine radical YD. in photosystem II by EPR spectroscopy using site specific isotope labelling in Spirodela oligorrhiza.  Chem. Phys. 294 (2003) 459-469.

27.   Matysik J, Alia A, Bhalu B, and Mohanty P.  Molecular mechanisms of quenching of reactive oxygen species by proline under stress in plants. Curr. Sci. 82 (2002) 525-532.

26.   Schulten Els AM, Matysik J, Alia A, Kiihne S, Raap J, Lugtenburg J, Gast P, Hoff AJ, and de Groot HJM. 13C MAS NMR and photo-CIDNP reveal a pronounced asymmetry in the electronic ground state of the special pair of Rhodobacter Sphaeroides reaction centres. Biochemistry 41 (2002) 8708-8717.

25.   Alia A, Mohanty P, and Matysik J. Effect of proline on the production of singlet oxygen. Amino acid 21 (2001) 195-200.

24.   Alia A, Matysik J, Soede-Huijbregts C, Baldus M, Raap J, Lugtenburg J, Gast P, van Gorkom HJ, Hoff AJ, de Groot HJM. Ultra high field MAS NMR dipolar correlation spectroscopy of histidine residues in light harvesting complex II from photosynthetic bacteria reveals internal charge transfer in the B850/his complex. J. Am. Chem. Soc. 123 (2001) 4803-4809.

23.   Matysik J, Schulten E, Alia A, Gast P, Raap J, Lugtenburg J, Hoff AJ, de Groot HJM. 13C nuclear-spin polarisation of histidine side chains and aliphatic ring carbons of bacteriochlorophyll and bacteriopheophytin cofactors in bacterial photosynthetic reaction centres observed by photo-CIDNP 13C magic angle spinning NMR. Biol. Chem. 382 (2001) 1271-1276.

22.   Alia A, Matysik J, Erkelens C, Hulsbergen FB, Gast P, Lugtenburg J, de Groot HJM. Bacteriochlorophyll/ imidazole and chlorophyll/imidazole complexes are negatively charged in an apolar environment. Chem. Phys. Lett. 330 (2000) 325-330.

21.   Matysik J, Alia A, Gast P, van Gorkom HJ, Hoff AJ, de Groot HJM. Photochemically induced dynamic nuclear polarization in reaction centres of photosystem II observed by 13C-solid-state NMR reveals a strongly asymmetric electronic structure of the P680•+ primary donor chlorophyll. Proc. Natl. Acad. Sci. USA 97 (2000) 9865-9870.

20.   Matysik J, Alia A, Nachtegaal G, van Gorkom HJ, Hoff AJ, and de Groot HJM. Solid-state 113Cd NMR investigations of the calcium-binding site in photosystem II membrane (accelerated publication) Biochemistry 39 (2000) 6751-6755.

19.   Matysik J, Alia A, Hollander JG, Egorova-Zachernyuk T, Gast P, and de Groot HJM. Sample illumination and photo-CIDNP in a magic-angle spinning NMR probe (invited article). Ind. J. Biochem. Biophys. 37 (2000)  418-423.

18.   Sakamoto S, Valverde R, Alia A, Chen THH, Murata N. Transformation with codA gene for choline oxidase enhances the freezing tolerance of Arabidopsis. Plant J. 22 (2000) 449-454.

17.   Alia A, Kondo Y, Saradhi PP, Nonaka H, Hayashi H, Chen THH, Murata N. Characterization of enhanced stress tolerance in transgenic Arabidopsis plants expressing the codA gene for bacterial choline oxidase. Plant Mol Biol. 40 (1999) 279-288.

16.   Alia A, Hayashi H, and Murata N. High temperature tolerance of Arabidopsis by engineering glycinebetaine synthesis. Plant J. 16 (1998) 155-161.

15.   Alia A, Hayashi H, Chen T.H.H, Murata N. Enhanced tolerance of Arabidopsis to low temperature stress during seed germination and early seedling growth by expressing choline oxidase for betaine synthesis. Plant Cell Environ. 21 (1998) 232-239.

14.   Sakamoto A, Alia A, Murata N. Genetic engineering of salt tolerance in rice: glycinebetaine accumulated in transgenic rice efficiently protected the photosynthetic activity under salt stress. Plant Mol Biol. 38 (1998) 1011-1019.

13.   Hayashi H, Alia A, Nonaka H, Chen THH, Murata N. Enhancement of seed germination under high-salt conditions in transgenic Arabidopsis expressing a bacterial codA gene for choline oxidase. J. Plant Res. 111 (1998) 357-362.

12.   Alia A, Saradhi PP, Mohanty P. Involvement of proline in protecting thylakoid membranes against free radical induced photodamage. J. Photochem. Photobiol. 38 (1997) 253-257.

11.   Hayashi H, Alia A, Mustardy L, Deshnium P, Ida M, Murata N. Transformation of Arabidopsis thaliana with the codA gene for choline oxidase; accumulation of glycine betaine and enhanced tolerance to salt and cold stress. Plant J. 12 (1997) 133-142.

10.   Alia A, Prasad KVSK, Saradhi PP. Zinc induced changes in the level of free radicals and proline in Brassica juncea and Cajanus cajan. Phytochemistry 39 (1995) 45-47.

9.     Saradhi PP, Alia A. Production and selection of somaclonal variants of Leucaena leucocephala with high carbondioxide assimilating potential. Energy Conserv. Management 36 (1995) 759-762.

8.     Saradhi PP, Alia A, Arora S, Prasad KVSK. Proline accumulates in plants exposed to UV radiation and protect against UV induced peroxidation. Biochem. Biophys. Res. Com. 209 (1995) 1-5.

7.     Alia A, Saradhi PP, and Mohanty P.  Proline in relation to free radical production in seedlings of Brassica juncea raised under sodium chloride stress. Plant Soil 156 (1993) 497-500.

6.     Saradhi PP, Alia A, Vani B. Inhibition of mitochondrial electron transport is the prime cause behind proline accumulation during mineral deficiency in Oryza sativa. Plant Soil 156 (1993) 465-468.

5.     Alia A, Saradhi P.P. Suppression in mitochondrial electron transport is the prime cause behind stress induced proline accumulation. Biochem. Biophys. Res. Commun. 193 (1993) 54-58.

4.     Alia A, Saradhi PP, Mohanty P. Enhancement of photosystem II photoreaction and high pH stability in thylakoids from cotyledonary leaves of Brassica juncea raised under sodium chloride stress. Physiol. Plant. 86 (1992) 189-196.

3.     Alia A, Mohanty P, Saradhi PP. Effect of sodium chloride on primary photochemical activities in cotyledonary leaves of Brassica juncea. Biochem. Physiol. Pflanzen 188 (1992) 1-12.

2.     Alia A, Saradhi PP, Mohanty P. Proline enhances primary photochemical activities in isolated thylakoid membranes of Brassica juncea by arresting photoinhibitory damage. Biochem. Biophys. Res. Commun. 181 (1991) 1238-1244.

1.     Alia A, Saradhi PP. Proline accumulation under heavy metal stress. J. Plant Physiol. 138 (1991) 554-55

Publications in books/proceedings

28.   Kara F, Schliebs F, Roßner S, Van der Linden A, de Groot HJM, Alia A A. Longitudinal monitoring of transverse relaxation time changes in the corpus callosum of a mouse model of Alzheimer’s disease. Proc. Intl. Soc. Mag. Reson. Med. 22 (2014) 4148.

27.   Alia A A, Kara F, Braakman N, van Buchem MA, Schliebs R. 2D L-COSY MR spectroscopy detects changes in brain glucose level in an Alzheimer mouse model. Proc. Intl. Soc. Mag. Reson. Med. 21 (2013) 2882.

26.   Kara F, Chen F, Ronen I, de Groot HJM, Matysik J, Alia A. Age-related changes in regional brain T1 and T2 relaxation times in the healthy mouse at 17.6 T. Proc. Intl. Soc. Mag. Reson. Med. 21 (2013) 2881.

25.   Alia A A, Kara F, Regional glutamate alterations in 11-month-old Tg2576 mouse model of Alzheimer’s disease detected by in vivo 1H magnetic resonance spectroscopy at 9.4 T. Proc. Intl. Soc. Mag. Reson. Med. 20 (2012) 995.

24.   Kara F, van Dongen ES, Schliebs R, van Buchem MA, de Groot HJM and Alia A A, Probing age-dependent cerebrovascular alterations in the Tg2576 mouse model of Alzheimer’s disease by magnetic resonance angiography at 17.6 T. Proc. Intl. Soc. Mag. Reson. Med. 20 (2012) 970.

23.   Kara F, Chen F, Matysik J and Alia A, In vivo measurement of T2 relaxation times in mouse brain at 17.6 Tesla. Proc. Intl. Soc. Mag. Reson. Med. 19 (2011) 4782.

22.   Kara F, Möbius K, van Buchem MA, de Groot HJM, Schliebs R and Alia A A, Changes in glucose level with age and its correlation with severity of plaque deposition in a transgenic model of Alzheimer’s disease. Proc. Intl. Soc. Mag. Reson. Med. 19 (2011) 4098.

21.    Alia A, Noémie H, Kara F and Hurlstone A, Ultra High Field Magnetic Resonance Microimaging in Zebrafish Model of Cystic Leukoencephalopathy, Proc. Intl. Soc. Mag. Reson. Med. 19 (2011) 4148.

20.   Van Duijn S, Kara F, Braakman N, Van Duinen SG, Natte R, Van Buchem MA, Alia A, 2D L-Cosy MR spectroscopy detects very early changes in the brain of Alzheimer mouse, Proc. Intl. Soc. Mag. Reson. Med. 18 (2010) 4257.

19.   Kara F, Braakman N, Van Buchem MA, de Groot HJM, Schliebs R, Alia A A, In Vivo Longitudinal Monitoring of Blood Flow Alterations in TG2576 Mouse Model of Alzheimer’s Disease, Proc. Intl. Soc. Mag. Reson. Med. 18 (2010) 4273.

18.   Alia A, Kabli S, He SN, Jagalska ES, Hurlstone A, Spaink HP, de Groot HJM, In Vivo Ultra High Field Magnetic Resonance Microimaging to Track the Development of Malignant Melanoma in Zebrafish, Proc. Intl. Soc. Mag. Reson. Med. 18 (2010) 730.

17.   Kara F, Alia A. Magnetic resonance angiography of the mouse cerebrovascular system at 17.6 T, Proc. Intl. Soc. Mag. Reson. Med. 18 (2010) 2247.

16.   Braakman N, Kara F, van Buchem MA, Schliebs R, de Groot HJM, Alia A A. In vivo localized two dimensional MR spectroscopy to compare the neurochemical profile in wild-type and transgenic mouse model of Alzheimer’s disease. Proc. Intl. Soc. Mag. Reson. Med. 17 (2009) 1089.

15.   Kara F, Ravensbergen J, Braakman N, van Buchem MA, Schliebs R, de Groot HJM, Alia A. MRI assessment of blood flow artifacts in a transgenic mouse model of Alzheimer’s disease. Proc. Intl. Soc. Mag. Reson. Med. 17 (2009) 1331.

14.   Braakman N, Matysik J, de Groot HJM, Schliebs R, Alia A. Correlation between neurochemical changes and development of Alzheimer’s plaques with age monitored by in vivo high resolution magnetic resonance microimaging and spectroscopy. Proc. Intl. Soc. Mag. Reson. Med. 16 (2008) 257.

13.  Braakman N, Oerther T, de Groot HJM, Alia A.  In Vivo High Resolution Localized Two Dimensional Magnetic Resonance Spectroscopy in Mouse Brain. Proc. Intl. Soc.Mag. Reson. Med. 16 (2008) 121.

12.   Kabli S, Spaink HP, de Groot HJM, Alia A. In Vivo High resolution Magnetic Resonance Spectroscopy of the Adult Zebrafish Brain at 9.4T. Proc. Intl. Soc. Mag. Reson. Med. 16 (2008) 113.

11.   Matysik J., Alia A, Gast P., Lugtenburg J., Hoff A.J., and de Groot H.J.M. Photochemically induced dynamic nuclear polarization in bacterial photosynthetic reaction centers observed by 13C solid-state NMR. The Future of Solid-State NMR(Eds. Suzanne Kiihne and Huub J.M. de Groot, Kluwer, Dordrecht) (2001) 215-225.

10.  Matysik J. Alia A A. The photophysics and photochemistry of cytochrome-c oxidase. Biophysical Processes in Living Systems (Ed. P. Pardha Sardhi, Science Publishers, Inc., Enfield (NH), USA & Plymouth, UK) (2001) 227-244.

9.     Sakamoto A, Hyashi H, Alia A, Chen THH, Murata N. Genetic engineering of glycinebetaine enhances tolerance to various stress. Plant Tolerance to Abiotic Stresses in Agriculture (Eds. J.H. Cherry, A. Rithcer, and R.D. Locy, Kluwer, Dordrecht) (2000) 95-104.

8.     Alia A, Matysik J, Mohanty P. Singlet oxygen scavenging activity of proline: Studies with spin trapping EPR spectroscopy. Toxicology and Environmental Health (Eds S.B. Vohora and V.P. Agarwal, Society Biosciences, Jamia Hamdard University/Aptech Publications, New Delhi) (1999) 121-124.

7.    Alia A, Matysik J, Soede-Huijbregts C, Gast P, Raap J, Lugtenburg J, de Groot HJM, van Gorkom HJ Selective 15N-isotope labelling of histidines in photosystem II reaction center of Spirodela oligorrhiza. Photosynthesis: Mechanisms and Effects (Ed. G. Garab, Kluwer, Dordrecht) (1998) 1009-1012.

6.     Matysik J, Alia A, van Gorkom HJ, de Groot HJM. Substitution of calcium by cadmium in photosystem II reaction center. Photosynthesis: Mechanisms and Effects(Ed. G. Garab, Kluwer, Dordrecht) (1998) 1423-1426.

5.     Hyashi H, Sakamoto A, Alia A, Murata N. Enhancement of stress tolerance by gene-engineering of betaine accumulation in plants. Photosynthesis: Mechanisms and Effects, (Ed. G. Garab, Kluwer, Dordrecht) (1998) 2419-2424.

4.     Saradhi PP, Alia A. Alleviation of salt stress induced suppression in growth by ethephon is associated with decline in proline accumulation. Proceedings of 22nd Annual Meeting of the Plant Growth Regulator Society of America (1995).

3.     Alia A, Saradhi PP, Mohanty P. Salt stress induced proline accumulation protects thylakoid membranes against photodamage. Photosynthesis: from Light to Biosphere, (Ed. P. Mathis, Kluwer, Dordrecht) (1995) 705-708.

2.     Alia A, Saradhi PP, Mohanty P. Plant Nutrition-from Genetic Engineering to Field Practice, (Ed. N.J. Barrow, Kluwer, Dordrecht) (1993) 731-734.

1.     Saradhi PP, Alia A, Vani B. Plant Nutrition-from Genetic Engineering to Field Practice, (Ed. N.J. Barrow, Kluwer, Dordrecht) (1993) 689-692.

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